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Thalassemic DNA-Containing Red Blood Cells Are under Oxidative Stress
Joint Authors
Prus, Eugenia
Dana, Mutaz
Fibach, Eitan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We studied the nature of enucleated RBCs containing DNA remnants, Howell-Jolly (HJ) RBCs and reticulocytes (retics), that are characteristically present in the circulation of thalassemic patients, especially after splenectomy.
Using flow cytometry methodology, we measured oxidative status parameters of these cells in patients with β-thalassemia.
In each patient studied, these cells had higher content of reactive oxygen species and exposed phosphatidylserine compared with their DNA-free counterparts.
These results suggest that oxidative stress in thalassemic developing erythroid precursors might, through DNA-breakage, generate HJ-retics and HJ-RBCs and that oxidative stress-induced externalization of phosphatidylserine is involved in the removal of these cells from the circulation by the spleen, a mechanism similar to that of the removal of senescent RBCs.
American Psychological Association (APA)
Dana, Mutaz& Prus, Eugenia& Fibach, Eitan. 2012. Thalassemic DNA-Containing Red Blood Cells Are under Oxidative Stress. Anemia،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510246
Modern Language Association (MLA)
Dana, Mutaz…[et al.]. Thalassemic DNA-Containing Red Blood Cells Are under Oxidative Stress. Anemia No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-510246
American Medical Association (AMA)
Dana, Mutaz& Prus, Eugenia& Fibach, Eitan. Thalassemic DNA-Containing Red Blood Cells Are under Oxidative Stress. Anemia. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510246