Ghrelin Cells in the Gastrointestinal Tract
Joint Authors
Source
International Journal of Peptides
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ghrelin is 28-amino-acid peptide that was discovered from the rat and human stomach in 1999.
Since the discovery of ghrelin, various functions of ghrelin, including growth hormone release, feeding behavior, glucose metabolism, memory, and also antidepressant effects, have been studied.
It has also been reported that ghrelin in the gastrointestinal tract has an important physiological effect on gastric acid secretion and gastrointestinal motility.
Ghrelin has a unique structure that is modified by O-acylation with n-octanoic acid at third serine residues, and this modification enzyme has recently been identified and named ghrelin O-acyl transferase (GOAT).
Ghrelin is considered to be a gut-brain peptide and is abundantly produced from endocrine cells in the gastrointestinal mucosa.
In the gastrointestinal tract, ghrelin cells are most abundant in the stomach and are localized in gastric mucosal layers.
Ghrelin cells are also widely distributed throughout the gastrointestinal tract.
In addition, abundance of ghrelin cells in the gastric mucosa is evolutionally conserved from mammals to lower vertebrates, indicating that gastric ghrelin plays important roles for fundamental physiological functions.
Ghrelin cells in the gastrointestinal tract are a major source of circulating plasma ghrelin, and thus understanding the physiology of these cells would reveal the biological significance of ghrelin.
American Psychological Association (APA)
Sakata, Ichiro& Sakai, Takafumi. 2010. Ghrelin Cells in the Gastrointestinal Tract. International Journal of Peptides،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-510252
Modern Language Association (MLA)
Sakata, Ichiro& Sakai, Takafumi. Ghrelin Cells in the Gastrointestinal Tract. International Journal of Peptides No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-510252
American Medical Association (AMA)
Sakata, Ichiro& Sakai, Takafumi. Ghrelin Cells in the Gastrointestinal Tract. International Journal of Peptides. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-510252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510252