Study of αB-Crystallin Expression in Gerbil BCAO Model of Transient Global Cerebral Ischemia
Joint Authors
Jiang, Zheng
Li, Ting
He, Wenfang
Zeng, Liuwang
Xiao, Han
Zhang, He
Yang, Binbin
Mo, Xiaoye
Zhang, Jie
Hu, Zhiping
Lu, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
αB-crystallin (α-BC), the fifth member of mammalian small heat shock protein family (HspB5), is known to be expressed in many tissues and has a distinctive interaction with cytoskeleton components.
In this study, we investigated that α-BC and microtubule-associated protein-2 (MAP-2), a neuron-specific cytoskeleton protein, were coexpressed in neurons of Gerbil cortex, while in subcortex Gerbil brains, we found that several MAP-2-negative glia cells also express α-BC.
When subjected to 10-minute bilateral carotid artery occlusion (BCAO), an increment was observed in α-BC-positive cells after 6-hour reperfusion and peaked at around 7 days after.
In the same circumstances, the number and the staining concentration of MAP-2 positive neurons significantly decreased immediately after 6-hour reperfusion, followed by a slow recovery, which is consistent with the increase of α-BC.
Our results suggested that α-BC plays an important role in brain ischemia, providing the early protection of neurons by giving intracellular supports through the maintenance of cytoskeleton and extracellular supports through the protection of glia cells.
American Psychological Association (APA)
Li, Ting& Mo, Xiaoye& Jiang, Zheng& He, Wenfang& Lu, Wei& Zhang, He…[et al.]. 2012. Study of αB-Crystallin Expression in Gerbil BCAO Model of Transient Global Cerebral Ischemia. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510254
Modern Language Association (MLA)
Li, Ting…[et al.]. Study of αB-Crystallin Expression in Gerbil BCAO Model of Transient Global Cerebral Ischemia. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-510254
American Medical Association (AMA)
Li, Ting& Mo, Xiaoye& Jiang, Zheng& He, Wenfang& Lu, Wei& Zhang, He…[et al.]. Study of αB-Crystallin Expression in Gerbil BCAO Model of Transient Global Cerebral Ischemia. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510254