MicroRNAs : New Regulators of Toll-Like Receptor Signalling Pathways
Joint Authors
He, Xiaobing
Jing, Zhizhong
Cheng, Guofeng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Toll-like receptors (TLRs), a critical family of pattern recognition receptors (PRRs), are responsible for the innate immune responses via signalling pathways to provide effective host defence against pathogen infections.
However, TLR-signalling pathways are also likely to stringently regulate tissue maintenance and homeostasis by elaborate modulatory mechanisms.
MicroRNAs (miRNAs) have emerged as key regulators and as an essential part of the networks involved in regulating TLR-signalling pathways.
In this review, we highlight our understanding of the regulation of miRNA expression profiles by TLR-signalling pathways and the regulation of TLR-signalling pathways by miRNAs.
We focus on the roles of miRNAs in regulating TLR-signalling pathways by targeting multiple molecules, including TLRs themselves, their associated signalling proteins and regulatory molecules, and transcription factors and functional cytokines induced by them, at multiple levels.
American Psychological Association (APA)
He, Xiaobing& Jing, Zhizhong& Cheng, Guofeng. 2014. MicroRNAs : New Regulators of Toll-Like Receptor Signalling Pathways. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-510267
Modern Language Association (MLA)
He, Xiaobing…[et al.]. MicroRNAs : New Regulators of Toll-Like Receptor Signalling Pathways. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-510267
American Medical Association (AMA)
He, Xiaobing& Jing, Zhizhong& Cheng, Guofeng. MicroRNAs : New Regulators of Toll-Like Receptor Signalling Pathways. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-510267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510267