Trypanocidal Activity of Thioamide-Substituted Imidazoquinolinone : Electrochemical Properties and Biological Effects
Joint Authors
Lombardo, Maria E.
Frank, Fernanda M.
Bollini, Mariela
Ciccarelli, Alejandra B.
Batlle, Alcira
Bruno, Ana M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Three thioamide-substituted imidazoquinolinone, which possess a heterocyclic center similar to tryptanthrin and are named C1, C2, and C3, were studied regarding (a) their in vitro anti-Trypanosoma cruzi activity, (b) their cytotoxicity and electrochemical behaviour, and (c) their effect on cell viability, redox state, and mitochondrial function.
The assayed compounds showed a significant activity against the proliferative forms, but only C1 showed activity on the trypomastigote form (for C1, IC50 epi=1.49 μM; IC50 amas=1.74 μM; and IC50 try=34.89 μM).
The presence of an antioxidant compound such as ascorbic acid or dithiotreitol induced a threefold increase in the antiparasitic activity, whereas glutathione had a dual effect depending on its concentration.
Our results indicate that these compounds, which exhibited low toxicity to the host cells, can be reduced inside the parasite by means of the pool of low molecular weight thiols, causing oxidative stress and parasite death by apoptosis.
The antiparasitic activity of the compounds studied could be explained by a loss of the capacity of the antioxidant defense system of the parasite to keep its intracellular redox state.
C1 could be considered a good candidate for in vivo evaluation.
American Psychological Association (APA)
Frank, Fernanda M.& Ciccarelli, Alejandra B.& Bollini, Mariela& Bruno, Ana M.& Batlle, Alcira& Lombardo, Maria E.. 2013. Trypanocidal Activity of Thioamide-Substituted Imidazoquinolinone : Electrochemical Properties and Biological Effects. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510335
Modern Language Association (MLA)
Frank, Fernanda M.…[et al.]. Trypanocidal Activity of Thioamide-Substituted Imidazoquinolinone : Electrochemical Properties and Biological Effects. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-510335
American Medical Association (AMA)
Frank, Fernanda M.& Ciccarelli, Alejandra B.& Bollini, Mariela& Bruno, Ana M.& Batlle, Alcira& Lombardo, Maria E.. Trypanocidal Activity of Thioamide-Substituted Imidazoquinolinone : Electrochemical Properties and Biological Effects. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510335