Tocilizumab for the Treatment of Rheumatoid Arthritis and Other Systemic Autoimmune Diseases : Current Perspectives and Future Directions
Joint Authors
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Interleukin (IL)-6 is a cytokine featuring redundancy and pleiotropic activity.
While IL-6, when transiently produced, contributes to host defense against acute environmental stress, continuous dysregulated IL-6 production plays a significant pathological role in several systemic autoimmune diseases.
In response to the expectation that IL-6 blockade would constitute a novel therapeutic strategy for the treatment of these diseases, tocilizumab, a humanized anti-IL-6 receptor antibody, was developed.
Clinical trials have verified the efficacy and the safety of tocilizumab for patients with rheumatoid arthritis, resulting in approval of this innovative biologic for the treatment of rheumatoid arthritis in more than 90 countries worldwide.
Pathological analyses of the effect of IL-6 on the development of autoimmune diseases and a considerable number of case reports and pilot studies have also indicated the beneficial effects of this antibody on other systemic autoimmune diseases, including systemic lupus erythematosus, systemic sclerosis, polymyositis, and large-vessel vasculitis.
American Psychological Association (APA)
Ogata, Atsushi& Tanaka, Toshio. 2012. Tocilizumab for the Treatment of Rheumatoid Arthritis and Other Systemic Autoimmune Diseases : Current Perspectives and Future Directions. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-510345
Modern Language Association (MLA)
Ogata, Atsushi& Tanaka, Toshio. Tocilizumab for the Treatment of Rheumatoid Arthritis and Other Systemic Autoimmune Diseases : Current Perspectives and Future Directions. International Journal of Rheumatology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-510345
American Medical Association (AMA)
Ogata, Atsushi& Tanaka, Toshio. Tocilizumab for the Treatment of Rheumatoid Arthritis and Other Systemic Autoimmune Diseases : Current Perspectives and Future Directions. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-510345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510345