Homeobox Genes and Melatonin Synthesis : Regulatory Roles of the Cone-Rod Homeobox Transcription Factor in the Rodent Pineal Gland
Joint Authors
Møller, Morten
Rath, Martin Fredensborg
Rohde, Kristian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nocturnal synthesis of melatonin in the pineal gland is controlled by a circadian rhythm in arylalkylamine N-acetyltransferase (AANAT) enzyme activity.
In the rodent, Aanat gene expression displays a marked circadian rhythm; release of norepinephrine in the gland at night causes a cAMP-based induction of Aanat transcription.
However, additional transcriptional control mechanisms exist.
Homeobox genes, which are generally known to encode transcription factors controlling developmental processes, are also expressed in the mature rodent pineal gland.
Among these, the cone-rod homeobox (CRX) transcription factor is believed to control pineal-specific Aanat expression.
Based on recent advances in our understanding of Crx in the rodent pineal gland, we here suggest that homeobox genes play a role in adult pineal physiology both by ensuring pineal-specific Aanat expression and by facilitating cAMP response element-based circadian melatonin production.
American Psychological Association (APA)
Rohde, Kristian& Møller, Morten& Rath, Martin Fredensborg. 2014. Homeobox Genes and Melatonin Synthesis : Regulatory Roles of the Cone-Rod Homeobox Transcription Factor in the Rodent Pineal Gland. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-510350
Modern Language Association (MLA)
Rohde, Kristian…[et al.]. Homeobox Genes and Melatonin Synthesis : Regulatory Roles of the Cone-Rod Homeobox Transcription Factor in the Rodent Pineal Gland. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-510350
American Medical Association (AMA)
Rohde, Kristian& Møller, Morten& Rath, Martin Fredensborg. Homeobox Genes and Melatonin Synthesis : Regulatory Roles of the Cone-Rod Homeobox Transcription Factor in the Rodent Pineal Gland. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-510350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510350