A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain

Abstract EN

Cancers, such as melanoma, that are associated with immune deficiencies are a major cause of morbidity and mortality in HIV-infected patients.

Once patients develop melanoma metastases to the brain, treatment is often limited to palliative surgery and/or radiation.

Ipilimumab, a CTLA-4 antagonist, has been shown to improve the median survival of patients with metastatic melanoma.

However, available data regarding the safety and efficacy of ipilimumab in HIV-infected patients who develop intracranial melanoma metastases is limited.

Here we report our experience administering ipilimumab to a patient with HIV-AIDS who developed multiple intracranial melanoma metastases.

Following treatment, our patient showed improvement in systemic tumor control without any apparent interference with antiretroviral treatment.