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Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders
Joint Authors
Ohsawa, Masato
Matsuda, Miyuki
Tamura, Kouichi
Yamashita, Akio
Tsurumi-Ikeya, Yuko
Tokita, Yasuo
Maeda, Akinobu
Azushima, Kengo
Wakui, Hiromichi
Umemura, Satoshi
Ohki, Kohji
Kanaoka, Tomohiko
Kobayashi, Ryu
Uneda, Kazushi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In the present study, we examined the therapeutic effects of olmesartan, an angiotensin II (Ang II) type 1 receptor (AT1R)-specific blocker, in genetically obese diabetic KKAy mice, a model of human metabolic disorders with visceral obesity, with a focus on an olmesartan effect on the adipose tissue.
Olmesartan treatment (3 mg/kg per day) for 4 weeks significantly lowered systolic blood pressure but did not affect body weight during the study period in KKAy mice.
However, there were three interesting findings possibly related to the pleiotropic effects of olmesartan on adipose tissue in KKAy mice: (1) an inhibitory effect on adipocyte hypertrophy, (2) a suppressive effect on IL-6 gene expression, and (3) an ameliorating effect on oxidative stress.
On the other hand, olmesartan exerted no evident influence on the adipose tissue expression of AT1R-associated protein (ATRAP), which is a molecule interacting with AT1R so as to inhibit pathological AT1R activation and is suggested to be an emerging molecular target in metabolic disorders with visceral obesity.
Collectively, these results suggest that the blood pressure lowering effect of olmesartan in KKAy mice is associated with an improvement in adipocyte, including suppression of adipocyte hypertrophy and inhibition of the adipose IL-6-oxidative stress axis.
Further study is needed to clarify the functional role of adipose ATRAP in the pleiotropic effects of olmesartan.
American Psychological Association (APA)
Maeda, Akinobu& Tamura, Kouichi& Wakui, Hiromichi& Ohsawa, Masato& Azushima, Kengo& Uneda, Kazushi…[et al.]. 2014. Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-510392
Modern Language Association (MLA)
Maeda, Akinobu…[et al.]. Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-510392
American Medical Association (AMA)
Maeda, Akinobu& Tamura, Kouichi& Wakui, Hiromichi& Ohsawa, Masato& Azushima, Kengo& Uneda, Kazushi…[et al.]. Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-510392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510392