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Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60
Joint Authors
Rizzetto, Lisa
Uccelletti, Daniela
Ferrero, Ileana
Goffrini, Paola
Zanni, Elena
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Oxidative damage, mitochondrial dysfunction, genomic instability, and telomere shortening represent all molecular processes proposed as causal factors in aging.
Lifespan can be increased by metabolism through an influence on such processes.
Glucose reduction extends chronological lifespan (CLS) of Saccharomyces cerevisiae through metabolic adaptation to respiration.
To answer the question if the reduced CLS could be ascribed to glucose per se or to glucose repression of respiratory enzymes, we used the Kluyveromyces lactis yeast, where glucose repression does not affect the respiratory function.
We identified the unique hexokinase, encoded by RAG5 gene, as an important player in influencing yeast lifespan by modulating mitochondrial functionality and the level of the mitochondrial chaperonin Hsp60.
In this context, this hexokinase might have a regulatory role in the influence of CLS, shedding new light on the complex regulation played by hexokinases.
American Psychological Association (APA)
Rizzetto, Lisa& Zanni, Elena& Uccelletti, Daniela& Ferrero, Ileana& Goffrini, Paola. 2012. Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-510401
Modern Language Association (MLA)
Rizzetto, Lisa…[et al.]. Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60. Journal of Aging Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-510401
American Medical Association (AMA)
Rizzetto, Lisa& Zanni, Elena& Uccelletti, Daniela& Ferrero, Ileana& Goffrini, Paola. Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-510401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510401