Early Detection of Brain Pathology Suggestive of Early AD Using Objective Evaluation of FDG-PET Scans
Joint Authors
Patterson, James C.
Takalkar, Amol
Pinkston, James B.
Lilien, David L.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The need for early detection of AD becomes critical as disease-modifying agents near the marketplace.
Here, we present results from a study focused on improvement in detection of metabolic deficits related to neurodegenerative changes consistent with possible early AD with statistical evaluation of FDG-PET brain images.
We followed 31 subjects at high risk or diagnosed with MCI/AD for 3 years.
15 met criteria for diagnosis of MCI, and five met criteria for AD.
FDG-PET scans were completed at initiation and termination of the study.
PET scans were read clinically and also evaluated objectively using Statistical Parametric Mapping (SPM).
Using standard clinical evaluation of the FDG-PET scans, 11 subjects were detected, while 18 were detected using SPM evaluation.
These preliminary results indicate that objective analyses may improve detection; however, early detection in at-risk normal subjects remains tentative.
Several FDA-approved software packages are available that use objective analyses, thus the capacity exists for wider use of this method for MCI/AD.
American Psychological Association (APA)
Patterson, James C.& Lilien, David L.& Takalkar, Amol& Pinkston, James B.. 2010. Early Detection of Brain Pathology Suggestive of Early AD Using Objective Evaluation of FDG-PET Scans. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-510403
Modern Language Association (MLA)
Patterson, James C.…[et al.]. Early Detection of Brain Pathology Suggestive of Early AD Using Objective Evaluation of FDG-PET Scans. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-510403
American Medical Association (AMA)
Patterson, James C.& Lilien, David L.& Takalkar, Amol& Pinkston, James B.. Early Detection of Brain Pathology Suggestive of Early AD Using Objective Evaluation of FDG-PET Scans. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-510403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510403