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Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part I : Program Implementation and Lessons Learned
Joint Authors
Taylor, Michael D.
Andersen, Melvin E.
Roper, Jerry M.
Dorman, David C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Concerns have been raised regarding environmental manganese exposure since high exposures have been associated with neurological disorders.
The USA Environmental Protection Agency most recent human health risk assessment of inhaled manganese conducted in 1993 identified specific areas of uncertainty regarding manganese pharmacokinetics.
This led to the development of a test rule under the USA Clean Air Act that required the generation of pharmacokinetic information on the inorganic manganese combustion products of the organometallic fuel additive methylcyclopentadienyl manganese tricarbonyl (MMT).
The Alternative Tier 2 testing program for MMT, described in this paper, has yielded substantial pharmacokinetic data and has enabled the generation of physiologically based pharmacokinetic (PBPK) models for manganese.
These models are capable of predicting tissue manganese concentrations across a variety of dose routes, levels, and durations while accounting for factors such as age, gender, and reproductive status, enabling the consideration of tissue dosimetry in future risk assessments.
American Psychological Association (APA)
Dorman, David C.& Andersen, Melvin E.& Roper, Jerry M.& Taylor, Michael D.. 2012. Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part I : Program Implementation and Lessons Learned. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-510409
Modern Language Association (MLA)
Dorman, David C.…[et al.]. Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part I : Program Implementation and Lessons Learned. Journal of Toxicology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-510409
American Medical Association (AMA)
Dorman, David C.& Andersen, Melvin E.& Roper, Jerry M.& Taylor, Michael D.. Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part I : Program Implementation and Lessons Learned. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-510409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510409