Serum Neopterin Is Not Increased in Obese Juveniles
Joint Authors
Freytag, Florian
Fuchs, Dietmar
Mangge, Harald
Bauer-Denk, Carmen
Weghuber, Daniel
Almer, Gunter
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Cardiovascular disease is associated with inflammation and immune activation, concentrations of immune activation markers like neopterin predict outcome in adults.
Methods.
Serum neopterin concentrations and early metabolic and pre-atherosclerotic symptoms were analyzed in 295 obese juveniles and 101 normal weight controls of similar age.
Additionally, the influence of a 12 months weight reduction program on neopterin levels was investigated in 31 obese juveniles.
Results.
Intima-media thickness of common carotid arteries (IMT) and the concentrations of C-reactive protein (CRP) were increased in the obese juveniles (P<.001).
Also triglycerides, oxidized LDL, fasted insulin levels, HOMA-index, leptin, liver transaminases and uric acid were increased compared to the controls.
However, serum neopterin was decreased in the obese versus non-obese juveniles (P<.03).
The intervention consisting of regular sports, nutritional devices, and a psychologic attendance led after 12 months to an increase of neopterin concentration (P<.05; paired test).
Conclusions.
Neopterin concentrations in juvenile obesity behaved considerably different from what was demonstrated in adults, levels did not correlate with metabolic and pre-atherosclerotic symptoms found in early phases although early vascular burden and chronic low grade inflammation was indicated by increased IMT and CRP.
Neopterin concentrations increased after a 12 months intervention program.
American Psychological Association (APA)
Mangge, Harald& Freytag, Florian& Almer, Gunter& Weghuber, Daniel& Bauer-Denk, Carmen& Fuchs, Dietmar. 2011. Serum Neopterin Is Not Increased in Obese Juveniles. Journal of Obesity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510414
Modern Language Association (MLA)
Mangge, Harald…[et al.]. Serum Neopterin Is Not Increased in Obese Juveniles. Journal of Obesity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-510414
American Medical Association (AMA)
Mangge, Harald& Freytag, Florian& Almer, Gunter& Weghuber, Daniel& Bauer-Denk, Carmen& Fuchs, Dietmar. Serum Neopterin Is Not Increased in Obese Juveniles. Journal of Obesity. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510414