Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells
Joint Authors
Conway, Edward M.
Yamaguchi, Seiji
Fukuda, Seiji
Onishi, Chie
Abe, Mariko
Pelus, Louis M.
Purevsuren, Jamiyan
Taketani, Takeshi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
ITD-Flt3 mutations are detected in leukemia stem cells (LSCs) in acute myeloid leukemia (AML) patients.
While antagonizing Survivin normalizes ITD-Flt3-induced acute leukemia, it also impairs hematopoietic stem cell (HSC) function, indicating that identification of differences in signaling pathways downstream of Survivin between LSC and HSC are crucial to develop selective Survivin-based therapeutic strategies for AML.
Using a Survivin-deletion model, we identified 1,096 genes regulated by Survivin in ITD-Flt3-transformed c-kit+, Sca-1+, and lineageneg (KSL) cells, of which 137 are deregulated in human LSC.
Of the 137, 124 genes were regulated by Survivin exclusively in ITD-Flt3+ KSL cells but not in normal CD34neg KSL cells.
Survivin-regulated genes in LSC connect through a network associated with the epidermal growth factor receptor signaling pathway and falls into various functional categories independent of effects on apoptosis.
Pathways downstream of Survivin in LSC that are distinct from HSC can be potentially targeted for selective anti-LSC therapy.
American Psychological Association (APA)
Fukuda, Seiji& Abe, Mariko& Onishi, Chie& Taketani, Takeshi& Purevsuren, Jamiyan& Yamaguchi, Seiji…[et al.]. 2010. Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells. Journal of Oncology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-510427
Modern Language Association (MLA)
Fukuda, Seiji…[et al.]. Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells. Journal of Oncology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-510427
American Medical Association (AMA)
Fukuda, Seiji& Abe, Mariko& Onishi, Chie& Taketani, Takeshi& Purevsuren, Jamiyan& Yamaguchi, Seiji…[et al.]. Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells. Journal of Oncology. 2010. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-510427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510427