Electroacupuncture-Induced Cholinergic Nerve Activation Enhances the Hypoglycemic Effect of Exogenous Insulin in a Rat Model of Streptozotocin-Induced Diabetes
Joint Authors
Chang, Shih-Liang
Ho, Wai-Jane
Lin, Jaung Geng
Lee, Yu-Chen
Chen, Ying-I
Li, Te-Mao
Tzeng, Chung-Yuh
Cheng, Yu-Wen
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study is to explore the mechanisms by which electroacupuncture (EA) enhances the hypoglycemic effect of exogenous insulin in a streptozotocin- (STZ-) diabetic rats.
Animals in the EA group were anesthetized and subjected to the insulin challenge test (ICT) and EA for 60 minutes.
In the control group, rats were subjected to the same treatment with the exception of EA stimulation.
Blood samples were drawn to measure changes in plasma glucose, free fatty acids (FFA), and insulin levels.
Western blot was used to assay proteins involved in insulin signaling.
Furthermore, atropine, hemicholinium-3 (HC-3), and Eserine were used to explore the relationship between EA and cholinergic nerve activation during ICT.
EA augmented the blood glucose-lowering effects of EA by activating the cholinergic nerves in STZ rats that had been exposed to exogenous insulin.
This phenomenon may be related to enhancement of insulin signaling rather than to changes in FFA concentration.
American Psychological Association (APA)
Lee, Yu-Chen& Li, Te-Mao& Tzeng, Chung-Yuh& Cheng, Yu-Wen& Chen, Ying-I& Ho, Wai-Jane…[et al.]. 2011. Electroacupuncture-Induced Cholinergic Nerve Activation Enhances the Hypoglycemic Effect of Exogenous Insulin in a Rat Model of Streptozotocin-Induced Diabetes. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510441
Modern Language Association (MLA)
Lee, Yu-Chen…[et al.]. Electroacupuncture-Induced Cholinergic Nerve Activation Enhances the Hypoglycemic Effect of Exogenous Insulin in a Rat Model of Streptozotocin-Induced Diabetes. Experimental Diabetes Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-510441
American Medical Association (AMA)
Lee, Yu-Chen& Li, Te-Mao& Tzeng, Chung-Yuh& Cheng, Yu-Wen& Chen, Ying-I& Ho, Wai-Jane…[et al.]. Electroacupuncture-Induced Cholinergic Nerve Activation Enhances the Hypoglycemic Effect of Exogenous Insulin in a Rat Model of Streptozotocin-Induced Diabetes. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510441