Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme
Joint Authors
Levesque, Georges
Ben Aissa, Manel
Perreault, Jean-Pierre
Bergeron, Lucien-Junior
April, Marie-Claude
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Alzheimer's disease (AD) etiological studies suggest that an elevation in amyloid-β peptides (Aβ) level contributes to aggregations of the peptide and subsequent development of the disease.
The major constituent of these amyloid peptides is the 1 to 40–42 residue peptide (Aβ40−42) derived from amyloid protein precursor (APP).
Most likely, reducing Aβ levels in the brain may block both its aggregation and neurotoxicity and would be beneficial for patients with AD.
Among the several possible ways to lower Aβ accumulation in the cells, we have selectively chosen to target the primary step in the Aβ cascade, namely, to reduce APP gene expression.
Toward this end, we engineered specific SOFA-HDV ribozymes, a new generation of catalytic RNA tools, to decrease APP mRNA levels.
Additionally, we demonstrated that APP-ribozymes are effective at decreasing APP mRNA and protein levels as well as Aβ levels in neuronal cells.
Our results could lay the groundwork for a new protective treatment for AD.
American Psychological Association (APA)
Ben Aissa, Manel& April, Marie-Claude& Bergeron, Lucien-Junior& Perreault, Jean-Pierre& Levesque, Georges. 2012. Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-510442
Modern Language Association (MLA)
Ben Aissa, Manel…[et al.]. Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-510442
American Medical Association (AMA)
Ben Aissa, Manel& April, Marie-Claude& Bergeron, Lucien-Junior& Perreault, Jean-Pierre& Levesque, Georges. Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-510442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510442