Nerium oleander Distillate Improves Fat and Glucose Metabolism in High-Fat Diet-Fed Streptozotocin-Induced Diabetic Rats
Joint Authors
Uney, Kamil
Yazihan, Nuray
Ermis Kaya, Ezgi
Bas, Ahmet Levent
Demirci, Sule
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes was induced by intraperitoneal injection of streptozotocin (35 mg/kg bw) in all rats of five groups after being fed for 2 weeks high-fat diet.
Type 2 diabetic Nerium-oleander- (NO-) administered groups received the NO distillate at a dose of 3.75, 37.5, and 375 μg/0.5 mL of distilled water (NO-0.1, NO-1, NO-10, resp.); positive control group had 0.6 mg glibenclamide/kg bw/d by gavage daily for 12 weeks.
Type 2 diabetic negative control group had no treatment.
NO distillate administration reduced fasting blood glucose, HbA1c, insulin resistance, total cholesterol, low density lipoprotein, atherogenic index, triglyceride-HDL ratio, insulin, and leptin levels.
Improved beta cell function and HDL concentration were observed by NO usage.
HDL percentage in total cholesterol of all NO groups was similar to healthy control.
NO-10 distillate enhanced mRNA expressions of peroxisome proliferator-activated-receptor- (PPAR-) α, β, and γ in adipose tissue and PPAR-α–γ in liver.
The findings from both in vivo and in vitro studies suggest that the considerable beneficial effect of NO distillate administration at a dose of 375 μg/0.5 mL of distilled water may offer new approaches to treatment strategies that target both fat and glucose metabolism in type 2 diabetes.
American Psychological Association (APA)
Bas, Ahmet Levent& Demirci, Sule& Yazihan, Nuray& Uney, Kamil& Ermis Kaya, Ezgi. 2012. Nerium oleander Distillate Improves Fat and Glucose Metabolism in High-Fat Diet-Fed Streptozotocin-Induced Diabetic Rats. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-510449
Modern Language Association (MLA)
Bas, Ahmet Levent…[et al.]. Nerium oleander Distillate Improves Fat and Glucose Metabolism in High-Fat Diet-Fed Streptozotocin-Induced Diabetic Rats. International Journal of Endocrinology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-510449
American Medical Association (AMA)
Bas, Ahmet Levent& Demirci, Sule& Yazihan, Nuray& Uney, Kamil& Ermis Kaya, Ezgi. Nerium oleander Distillate Improves Fat and Glucose Metabolism in High-Fat Diet-Fed Streptozotocin-Induced Diabetic Rats. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-510449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510449