Characterization of the Gene BmEm4, a Homologue of Drosophila E(spl)m4, from the Silkworm, Bombyx mori
Joint Authors
Zhang, Yaozhou
Lv, Zhengbing
Zeng, Fenghui
Chen, Jianqing
Liu, Lili
Sheng, Qing
Chen, Jian
Wu, Xiangfu
Nie, Zuoming
Xie, Hongxia
Wang, Dan
Yu, Wei
Source
Comparative and Functional Genomics
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The Drosophila E(spl)m4 gene contains some highly conserved motifs (such as the Brd box, GY box, K box, and CAAC motif) in its 3′ untranslated region (3′UTR).
It was shown to be a microRNA target gene in Drosophila and to play an important role in the regulation of neurogenesis.
We identified a homologue of the E(spl)m4 gene from Bombyx mori called BmEm4 and examined the expression patterns of BmEm4 mRNA and protein.
There was a lack of correlation in the expression of the mRNA and protein between the different developmental stages, which raises the possibility of posttranscriptional regulation of the BmEm4 mRNA.
Consistent with this idea is the finding that the 3′ UTR contains two putative binding sites for microRNAs.
Moreover, given that the expression is the highest in the larval head, as confirmed by immunohistochemistry, we propose that BmEm4 may also be involved in the regulation of neurogenesis.
Immunostaining indicated that BmEm4 is located primarily in the cytoplasm.
American Psychological Association (APA)
Zeng, Fenghui& Xie, Hongxia& Nie, Zuoming& Chen, Jian& Lv, Zhengbing& Chen, Jianqing…[et al.]. 2009. Characterization of the Gene BmEm4, a Homologue of Drosophila E(spl)m4, from the Silkworm, Bombyx mori. Comparative and Functional Genomics،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-510483
Modern Language Association (MLA)
Zeng, Fenghui…[et al.]. Characterization of the Gene BmEm4, a Homologue of Drosophila E(spl)m4, from the Silkworm, Bombyx mori. Comparative and Functional Genomics No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-510483
American Medical Association (AMA)
Zeng, Fenghui& Xie, Hongxia& Nie, Zuoming& Chen, Jian& Lv, Zhengbing& Chen, Jianqing…[et al.]. Characterization of the Gene BmEm4, a Homologue of Drosophila E(spl)m4, from the Silkworm, Bombyx mori. Comparative and Functional Genomics. 2009. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-510483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510483