Antioxidant Therapy in Nonalcoholic Steatohepatitis

Abstract EN

Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population.

It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology.

Exercise and diet, which are the mainstay of therapy, are difficult to achieve and maintain with a disappointing long-term compliance record.

There is growing literature on the potential for antioxidant therapy.

The recent literature strongly suggests that vitamin E supplementation and other putative free radical scavengers and/or antioxidants are beneficial in improving biochemical and histological parameters in NASH.