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A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts
Joint Authors
Sousa, João Paulo Barreto de
Bastos, Jairo Kennup
Praça, Fabíola Silva Garcia
Miranda, Mariza Abreu
Bentley, Maria Vitória Lopes Badra
McChesney, James Dewey
Tiossi, Renata Fabiane Jorge
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Solanum lycocarpum (Solanaceae) is native to the Brazilian Cerrado.
Fruits of this species contain the glycoalkaloids solasonine (SN) and solamargine (SM), which display antiparasitic and anticancer properties.
A method has been developed for the extraction and HPLC-UV analysis of the SN and SM in different parts of S.
lycocarpum, mainly comprising ripe and unripe fruits, leaf, and stem.
This analytical method was validated and gave good detection response with linearity over a dynamic range of 0.77–1000.00 μg mL−1 and recovery in the range of 80.92–91.71%, allowing a reliable quantitation of the target compounds.
Unripe fruits displayed higher concentrations of glycoalkaloids (1.04% ± 0.01 of SN and 0.69% ± 0.00 of SM) than the ripe fruits (0.83% ± 0.02 of SN and 0.60% ± 0.01 of SM).
Quantitation of glycoalkaloids in the alkaloidic extract gave 45.09% ± 1.14 of SN and 44.37% ± 0.60 of SM, respectively.
American Psychological Association (APA)
Tiossi, Renata Fabiane Jorge& Miranda, Mariza Abreu& Sousa, João Paulo Barreto de& Praça, Fabíola Silva Garcia& Bentley, Maria Vitória Lopes Badra& McChesney, James Dewey…[et al.]. 2012. A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts. Journal of Analytical Methods in Chemistry،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510505
Modern Language Association (MLA)
Tiossi, Renata Fabiane Jorge…[et al.]. A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts. Journal of Analytical Methods in Chemistry No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-510505
American Medical Association (AMA)
Tiossi, Renata Fabiane Jorge& Miranda, Mariza Abreu& Sousa, João Paulo Barreto de& Praça, Fabíola Silva Garcia& Bentley, Maria Vitória Lopes Badra& McChesney, James Dewey…[et al.]. A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts. Journal of Analytical Methods in Chemistry. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510505