Impaired Sympathoadrenal Axis Function Contributes to Enhanced Insulin Secretion in Prediabetic Obese Rats
Joint Authors
Grassiolli, Sabrina
Torrezan, Rosana
de Freitas Mathias, Paulo Cezar
Marangon, Paula Beatriz
Gravena, Clarice
de Oliveira, Júlio Cézar
Garcia, Raúl Marcel González
Andreazzi, Ana Eliza
Martins, Adriana Gallego
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The involvement of sympathoadrenal axis activity in obesity onset was investigated using the experimental model of treating neonatal rats with monosodium L-glutamate.
To access general sympathetic nervous system activity, we recorded the firing rates of sympathetic superior cervical ganglion nerves in animals.
Catecholamine content and secretion from isolated adrenal medulla were measured.
Intravenous glucose tolerance test was performed, and isolated pancreatic islets were stimulated with glucose and adrenergic agonists.
The nerve firing rate of obese rats was decreased compared to the rate for lean rats.
Basal catecholamine secretion decreased whereas catecholamine secretion induced by carbachol, elevated extracellular potassium, and caffeine in the isolated adrenal medulla were all increased in obese rats compared to control.
Both glucose intolerance and hyperinsulinaemia were observed in obese rats.
Adrenaline strongly inhibited glucose-induced insulin secretion in obese animals.
These findings suggest that low sympathoadrenal activity contributes to impaired glycaemic control in prediabetic obese rats.
American Psychological Association (APA)
Andreazzi, Ana Eliza& Grassiolli, Sabrina& Marangon, Paula Beatriz& Martins, Adriana Gallego& de Oliveira, Júlio Cézar& Torrezan, Rosana…[et al.]. 2011. Impaired Sympathoadrenal Axis Function Contributes to Enhanced Insulin Secretion in Prediabetic Obese Rats. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-510516
Modern Language Association (MLA)
Andreazzi, Ana Eliza…[et al.]. Impaired Sympathoadrenal Axis Function Contributes to Enhanced Insulin Secretion in Prediabetic Obese Rats. Experimental Diabetes Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-510516
American Medical Association (AMA)
Andreazzi, Ana Eliza& Grassiolli, Sabrina& Marangon, Paula Beatriz& Martins, Adriana Gallego& de Oliveira, Júlio Cézar& Torrezan, Rosana…[et al.]. Impaired Sympathoadrenal Axis Function Contributes to Enhanced Insulin Secretion in Prediabetic Obese Rats. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-510516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510516