Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice
Joint Authors
Navab, Mohamad
Lusis, Aldons J.
Ishikawa, Kazunobu
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To elucidate roles of heme oxygenase-1 (HO-1) in cardiovascular system, we have analyzed one-year-old HO-1-knockout mice.
Homozygous HO-1-knockout mice had severe aortitis and coronary arteritis with mononuclear cellular infiltration and fatty streak formation even on a standard chow diet.
Levels of plasma total cholesterol and HDL were similar among the three genotypes.
However, homozygous HO-1-knockout mice had lower body weight and plasma triglyceride.
HO-1-deficiency resulted in alteration of the composition of HDL.
The ratio of apolipoprotein AI to AII in HO-1-knockout mice was reduced about 10-fold as compared to wild-type mice.
In addition, paraoxonase, an enzyme against oxidative stress, was reduced less than 50% in HO-1-knockout mice.
The knockout mice also exhibited significant elevation of plasma lipid hydroperoxides.
This study using aged HO-1-knockout mice strengthened the idea that HO-1 functions to suppress systemic inflammation in artery wall and prevents plasma lipid peroxidation.
American Psychological Association (APA)
Ishikawa, Kazunobu& Navab, Mohamad& Lusis, Aldons J.. 2012. Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-510539
Modern Language Association (MLA)
Ishikawa, Kazunobu…[et al.]. Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice. International Journal of Hypertension No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-510539
American Medical Association (AMA)
Ishikawa, Kazunobu& Navab, Mohamad& Lusis, Aldons J.. Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-510539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510539