Neuroendocrine Carcinoma of the Stomach : A Case Study

Abstract EN

Gastric neuroendocrine carcinomas are rare and have a poor prognosis, and the diagnostic criteria for this disease have recently changed.

We herein report a case of sporadic gastric neuroendocrine carcinoma.

A 75-year-old man was referred to our hospital with epigastric pain.

Endoscopic examination revealed a localized ulcerative lesion (diameter, 4 cm) at the upper stomach.

The diagnosis on biopsy was neuroendocrine carcinoma.

Total gastrectomy with D2 lymphadenectomy, splenectomy, and cholecystectomy was performed.

Pathologically, the tumor infiltrated the subserosal layer, and 6/49 lymph nodes were involved.

The tumor was uniform in shape and arranged in a rosette-like structure to form solid nests, with medium-sized, round-to-cuboid-shaped tumor cells and intense mitosis 46/10 HPF.

It was positive for synaptophysin and chromogranin A, and the Ki-67 labeling index was 70–80%.

The diagnosis of neuroendocrine carcinoma was made according to the WHO 2010 criteria.

The patient was followed up for three years without recurrence.