![](/images/graphics-bg.png)
Interferon Alpha in Systemic Lupus Erythematosus
Joint Authors
Poole, Brian D.
Salloum, Rafah
Niewold, Timothy B.
Clark, Daniel N.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The pleiotropic cytokine interferon alpha is involved in multiple aspects of lupus etiology and pathogenesis.
Interferon alpha is important under normal circumstances for antiviral responses and immune activation.
However, heightened levels of serum interferon alpha and expression of interferon response genes are common in lupus patients.
Lupus-associated autoantibodies can drive the production of interferon alpha and heightened levels of interferon interfere with immune regulation.
Several genes in the pathways leading to interferon production or signaling are associated with risk for lupus.
Clinical and cellular manifestations of excess interferon alpha in lupus combined with the genetic risk factors associated with interferon make this cytokine a rare bridge between genetic risk and phenotypic effects.
Interferon alpha influences the clinical picture of lupus and may represent a therapeutic target.
This paper provides an overview of the cellular, genetic, and clinical aspects of interferon alpha in lupus.
American Psychological Association (APA)
Niewold, Timothy B.& Clark, Daniel N.& Salloum, Rafah& Poole, Brian D.. 2010. Interferon Alpha in Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-510564
Modern Language Association (MLA)
Niewold, Timothy B.…[et al.]. Interferon Alpha in Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-510564
American Medical Association (AMA)
Niewold, Timothy B.& Clark, Daniel N.& Salloum, Rafah& Poole, Brian D.. Interferon Alpha in Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-510564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510564