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Silicon-Based Technology for Ligand-Receptor Molecular Identification
Joint Authors
Rendina, Ivo
De Stefano, Luca
Sanges, Carmen
Arcari, Paolo
Orabona, Emanuele
Scala, Giuseppe
Rea, Ilaria
Migliaccio, Nunzia
Lamberti, Annalisa
Source
Journal of Atomic, Molecular, and Optical Physics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
One of the most important goals in the fields of biology and medicine is the possibility to dispose of efficient tools for the characterization of the extraordinary complexity of ligand-receptor interactions.
To approach this theme, we explored the use of crystalline silicon (cSi) technology for the realization of a biotechnological device in which the ligand-receptor interactions are revealed by means of optical measurements.
Here, we describe a chemical procedure for the functionalization of microwell etched on silicon wafers, and the subsequent anchoring of biological molecules like an antibody anti-A20 murine lymphoma cell line.
The optical analysis of the interaction on the biochips between the bound biomolecule and their corresponding ligand indicated that the functionalized cSi is suitable for this application.
American Psychological Association (APA)
Lamberti, Annalisa& Sanges, Carmen& Migliaccio, Nunzia& De Stefano, Luca& Rea, Ilaria& Orabona, Emanuele…[et al.]. 2012. Silicon-Based Technology for Ligand-Receptor Molecular Identification. Journal of Atomic, Molecular, and Optical Physics،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510566
Modern Language Association (MLA)
Lamberti, Annalisa…[et al.]. Silicon-Based Technology for Ligand-Receptor Molecular Identification. Journal of Atomic, Molecular, and Optical Physics No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-510566
American Medical Association (AMA)
Lamberti, Annalisa& Sanges, Carmen& Migliaccio, Nunzia& De Stefano, Luca& Rea, Ilaria& Orabona, Emanuele…[et al.]. Silicon-Based Technology for Ligand-Receptor Molecular Identification. Journal of Atomic, Molecular, and Optical Physics. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510566