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Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of Ni(II) with 1,10-Phenanthroline and Heterocyclic Schiff Bases
Joint Authors
Ira,
Sathish kumar K
Chityala, Vijay kumar
Prashanthi, Y.
Kiranmai, K.
Shivaraj,
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mixed ligand complexes of Ni(II) with 1,10-phenanthroline (1,10-Phen) and Schiff bases L1(MIIMP); L2(CMIIMP); L3(EMIIMP); L4(MIIMNP); L5(MEMIIMP); L6(BMIIMP); L7(MMIIMP); L8(MIIBD) have been synthesized.
These metal chelates have been characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, Mass, UV-Vis, magnetic moments, and thermogravimetric (TG&DTA) analysis.
Spectral data showed that the 1,10-phenanthroline act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms and Schiff bases acts as monobasic bidentate coordinating through NO donor atoms.
All Ni(II) complexes appear to have an octahedral geometry.
The antimicrobial activity of mixed ligand complexes has been studied by screening against various microorganisms, it is observed that the activity enhances upon coordination.
The DNA binding studies have been investigated by UV-Vis spectroscopy, and the experimental results indicate that these complexes bind to CT DNA with the intrinsic binding constant Kb=2.5±0.2×105 M−1.
MTT is used to test the anticancer effect of the complexes with HL60 tumor cell.
The inhibition ratio was accelerated by increasing the dosage, and it had significant positive correlation with the medication dosage.
American Psychological Association (APA)
Prashanthi, Y.& Kiranmai, K.& Ira, & Sathish kumar K& Chityala, Vijay kumar& Shivaraj,. 2012. Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of Ni(II) with 1,10-Phenanthroline and Heterocyclic Schiff Bases. Bioinorganic Chemistry and Applications،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510578
Modern Language Association (MLA)
Prashanthi, Y.…[et al.]. Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of Ni(II) with 1,10-Phenanthroline and Heterocyclic Schiff Bases. Bioinorganic Chemistry and Applications No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-510578
American Medical Association (AMA)
Prashanthi, Y.& Kiranmai, K.& Ira, & Sathish kumar K& Chityala, Vijay kumar& Shivaraj,. Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of Ni(II) with 1,10-Phenanthroline and Heterocyclic Schiff Bases. Bioinorganic Chemistry and Applications. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510578