Comparative Morphology of Dendritic Arbors in Populations of Purkinje Cells in Mouse Sulcus and Apex
Joint Authors
Abdelhack, Mohamed
Nedelescu, Hermina
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Foliation divides the mammalian cerebellum into structurally distinct subdivisions, including the concave sulcus and the convex apex.
Purkinje cell (PC) dendritic morphology varies between subdivisions and changes significantly ontogenetically.
Since dendritic morphology both enables and limits sensory-motor circuit function, it is important to understand how neuronal architectures differ between brain regions.
This study employed quantitative confocal microcopy to reconstruct dendritic arbors of cerebellar PCs expressing green fluorescent protein and compared arbor morphology between PCs of sulcus and apex in young and old mice.
Arbors were digitized from high z-resolution (0.25 µm) image stacks using an adaptation of Neurolucida’s (MBF Bioscience) continuous contour tracing tool, designed for drawing neuronal somata.
Reconstructed morphologies reveal that dendritic arbors of sulcus and apex exhibit profound differences.
In sulcus, 72% of the young PC population possesses two primary dendrites, whereas in apex, only 28% do.
Spatial constraints in the young sulcus cause significantly more dendritic arbor overlap than in young apex, a distinction that disappears in adulthood.
However, adult sulcus PC arbors develop a greater number of branch crossings.
These results suggest developmental neuronal plasticity that enables cerebellar PCs to attain correct functional adult architecture under different spatial constraints.
American Psychological Association (APA)
Nedelescu, Hermina& Abdelhack, Mohamed. 2013. Comparative Morphology of Dendritic Arbors in Populations of Purkinje Cells in Mouse Sulcus and Apex. Neural Plasticity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-510583
Modern Language Association (MLA)
Nedelescu, Hermina& Abdelhack, Mohamed. Comparative Morphology of Dendritic Arbors in Populations of Purkinje Cells in Mouse Sulcus and Apex. Neural Plasticity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-510583
American Medical Association (AMA)
Nedelescu, Hermina& Abdelhack, Mohamed. Comparative Morphology of Dendritic Arbors in Populations of Purkinje Cells in Mouse Sulcus and Apex. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-510583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510583