Regulation of Vascular Function on Posttranscriptional Level
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions.
Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein expression on posttranscriptional level.
Both alternative splicing and miRNAs were shown to influence cardiovascular functions, such as endothelial thrombogenicity and the vascular tone, by regulating the expression of several vascular proteins and their isoforms, such as Tissue Factor (TF) or the endothelial nitric oxide synthase (eNOS).
This review will summarize and discuss the latest findings on the (patho)physiologic role of alternative splicing processes as well as of miRNAs on modulation of vascular functions, such as coagulation, thrombosis, and regulation of the vascular tone.
American Psychological Association (APA)
Eisenreich, Andreas. 2013. Regulation of Vascular Function on Posttranscriptional Level. Thrombosis،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510606
Modern Language Association (MLA)
Eisenreich, Andreas. Regulation of Vascular Function on Posttranscriptional Level. Thrombosis No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-510606
American Medical Association (AMA)
Eisenreich, Andreas. Regulation of Vascular Function on Posttranscriptional Level. Thrombosis. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510606