Evaluating the Effects and Safety of Intravenous Lipid Emulsion on Haloperidol-Induced Neurotoxicity in Rabbit
Joint Authors
Mohammadpour, Amir Hooshang
Hosseinzadeh, Hossein
Etemad, Leila
Memar, Bahram
Vahabzadeh, Maryam
Moshiri, Mohammad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There are many reports on the effect of intravenous lipid emulsion (ILE) as an antidote in drugs related toxicities.
We determined the effects of ILE on neurotoxicity of haloperidol (HA), a highly lipophilic antipsychotic, as a model of antipsychotics poisoning.
We used six groups of five male rabbits.
Two groups received distilled water intravenously followed by infusions of either 18 mL/kg of normal saline or ILE 20%, after 30 minutes.
The third group received 18 mL/kg of normal saline after HA (2.6 mg/kg) administration.
The three other groups received ILE 20% solution (6, 12, and 18 mL/kg) following HA injection.
Catalepsy scores, temperature, pupil size, and mortality rate were measured at 0, 0.5, 1, 2, 3, 4, 8, and 24 hours after HA administration began.
Blood and tissue samples were taken from all animals at 24 hours or at death time for biochemical, cell count, and pathological studies.
ILE reversed cataleptic scores, miotic pupils, and hypothermia of HA intoxication much faster than normal saline (P<0.001).
Biochemical complications and mortality rate of the animals were significantly higher in the HA + 18 mL/Kg ILE group.
ILE reversed sings of HA neurotoxicity; however, synergistic effect of high dose of ILE and HA increased complications and mortality.
American Psychological Association (APA)
Moshiri, Mohammad& Mohammadpour, Amir Hooshang& Vahabzadeh, Maryam& Etemad, Leila& Memar, Bahram& Hosseinzadeh, Hossein. 2014. Evaluating the Effects and Safety of Intravenous Lipid Emulsion on Haloperidol-Induced Neurotoxicity in Rabbit. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510645
Modern Language Association (MLA)
Moshiri, Mohammad…[et al.]. Evaluating the Effects and Safety of Intravenous Lipid Emulsion on Haloperidol-Induced Neurotoxicity in Rabbit. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-510645
American Medical Association (AMA)
Moshiri, Mohammad& Mohammadpour, Amir Hooshang& Vahabzadeh, Maryam& Etemad, Leila& Memar, Bahram& Hosseinzadeh, Hossein. Evaluating the Effects and Safety of Intravenous Lipid Emulsion on Haloperidol-Induced Neurotoxicity in Rabbit. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510645