Trial Designs Likely to Meet Valid Long-Term Alzheimer's Disease Progression Effects : Learning from the Past, Preparing for the Future
Joint Authors
Kemp, Aaron S.
Bullock, Roger
Ryan, J. Michael
Romano, Steven J.
Grossberg, George T.
Arnold, Douglas L.
Streiner, David L.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The International Society for CNS Clinical Trials and Methodology (ISCTM) held its 4th Annual Autumn Conference in Toronto, Ontario, October 6-7, 2008.
The purpose of the present report is to provide an overview of one of the sessions at the conference which focused on the designs and methodologies to be applied in clinical trials of new treatments for Alzheimer's disease (AD) with purported “disease-modifying” effects.
The session began with a discussion of how neuroimaging has been applied in multiple sclerosis clinical trials (another condition for which disease modification claims have been achieved).
The next two lectures provided a pharmaceutical industry perspective on some of the specific challenges and possible solutions for designing trials to measure disease progression and/or modification.
The final lecture provided an academic viewpoint and the closing discussion included additional academic and regulatory perspectives on trial designs, methodologies, and statistical issues relevant to the disease modification concept.
American Psychological Association (APA)
Kemp, Aaron S.& Grossberg, George T.& Romano, Steven J.& Arnold, Douglas L.& Ryan, J. Michael& Bullock, Roger…[et al.]. 2009. Trial Designs Likely to Meet Valid Long-Term Alzheimer's Disease Progression Effects : Learning from the Past, Preparing for the Future. International Journal of Alzheimer's Disease،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-510646
Modern Language Association (MLA)
Kemp, Aaron S.…[et al.]. Trial Designs Likely to Meet Valid Long-Term Alzheimer's Disease Progression Effects : Learning from the Past, Preparing for the Future. International Journal of Alzheimer's Disease No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-510646
American Medical Association (AMA)
Kemp, Aaron S.& Grossberg, George T.& Romano, Steven J.& Arnold, Douglas L.& Ryan, J. Michael& Bullock, Roger…[et al.]. Trial Designs Likely to Meet Valid Long-Term Alzheimer's Disease Progression Effects : Learning from the Past, Preparing for the Future. International Journal of Alzheimer's Disease. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-510646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510646