Durable Hematological and Major Cytogenetic Response in a Patient with Isolated 20q Deletion Myelodysplastic Syndrome Treated with Lenalidomide
Joint Authors
Ninan, Mary
Jana, Bagi
Khanfar, Anas
Source
Case Reports in Oncological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Myelodysplastic syndrome (MDS) is a clonal bone marrow disorder characterized by ineffective hematopoiesis.
It is characterized by peripheral blood cytopenia and significant risk of progression to acute myeloid leukemia result.
Deletion of the long arm of chromosome 20 (20q deletion) is present in 3–7% of patients with MDS.
Lenalidomide is an immunomodulatory agent with antiangiogenic activity.
It is FDA approved for the treatment of anemia in patients with low or int-1 risk MDS with chromosome 5q deletion with or without additional cytogenetic abnormalities.
Study of lenalidomide in patients with MDS without 5q deletion but other karyotypic abnormalities demonstrated meaningful activity in transfusion dependent patients; however, response of patients with isolated 20q deletion to lenalidomide is not known.
We are reporting a patient with 20q deletion MDS treated with lenalidomide after he failed to respond to azacytidine; to our knowledge this is the first report of a patient with isolated 20q deletion treated with lenalidomide.
American Psychological Association (APA)
Jana, Bagi& Khanfar, Anas& Ninan, Mary. 2014. Durable Hematological and Major Cytogenetic Response in a Patient with Isolated 20q Deletion Myelodysplastic Syndrome Treated with Lenalidomide. Case Reports in Oncological Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-510668
Modern Language Association (MLA)
Jana, Bagi…[et al.]. Durable Hematological and Major Cytogenetic Response in a Patient with Isolated 20q Deletion Myelodysplastic Syndrome Treated with Lenalidomide. Case Reports in Oncological Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-510668
American Medical Association (AMA)
Jana, Bagi& Khanfar, Anas& Ninan, Mary. Durable Hematological and Major Cytogenetic Response in a Patient with Isolated 20q Deletion Myelodysplastic Syndrome Treated with Lenalidomide. Case Reports in Oncological Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-510668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510668