Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease : An Update on Management
Joint Authors
Hagar, Ward
Lutty, Gerard A.
Darbari, Deepika S.
Hoppe, Carolyn
Dampier, Carlton
Ballas, Samir K.
Wang, Winfred C.
Kesen, Muge R.
Malik, Punam
Osunkwo, Ifeyinwa
Goldberg, Morton F.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-55, 55 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-01
Country of Publication
Egypt
No. of Pages
55
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG → GTG) in exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position 6 of the β globin polypeptide chain.
Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing multiple phenotypic expressions that constitute the various complications of sickle cell disease in general and sickle cell anemia in particular.
The disease itself is chronic in nature but many of its complications are acute such as the recurrent acute painful crises (its hallmark), acute chest syndrome, and priapism.
These complications vary considerably among patients, in the same patient with time, among countries and with age and sex.
To date, there is no well-established consensus among providers on the management of the complications of sickle cell disease due in part to lack of evidence and in part to differences in the experience of providers.
It is the aim of this paper to review available current approaches to manage the major complications of sickle cell disease.
We hope that this will establish another preliminary forum among providers that may eventually lead the way to better outcomes.Erratum to “Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management”dx.doi.org/10.1155/2013/861251
American Psychological Association (APA)
Ballas, Samir K.& Kesen, Muge R.& Goldberg, Morton F.& Lutty, Gerard A.& Dampier, Carlton& Osunkwo, Ifeyinwa…[et al.]. 2012. Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease : An Update on Management. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-55.
https://search.emarefa.net/detail/BIM-510671
Modern Language Association (MLA)
Ballas, Samir K.…[et al.]. Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease : An Update on Management. The Scientific World Journal No. 2012 (2012), pp.1-55.
https://search.emarefa.net/detail/BIM-510671
American Medical Association (AMA)
Ballas, Samir K.& Kesen, Muge R.& Goldberg, Morton F.& Lutty, Gerard A.& Dampier, Carlton& Osunkwo, Ifeyinwa…[et al.]. Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease : An Update on Management. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-55.
https://search.emarefa.net/detail/BIM-510671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510671