Vitamin D Receptor Agonists : Suitable Candidates as Novel Therapeutic Options in Autoimmune Inflammatory Myopathy
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The primary aim in the treatment of autoimmune inflammatory myopathies (IMs) is to recover muscle function.
The presence of immune/inflammatory cell infiltrates within muscle tissues represents the common feature of different IM subtypes, albeit a correlation between muscular damage extent and inflammation degree is often lacking.
Treatments for IMs are based on life-long immunosuppressive therapy, with the well known adverse effects; recovery is incomplete for many patients.
More effective therapies, with reduced side-effects, are highly desirable.
Vitamin D receptor (VDR) agonists emerge to retain pleiotropic anti-inflammatory properties, since they regulate innate and adaptive immunity by switching the immune response from proinflammatory T helper 1 (Th1) type to tolerogenic T helper 2 (Th2) type dominance.
In skeletal muscle cells less hypercalcemic VDR ligands target powerful mediators of inflammation, such as TNFα and TNFα driven paths, without affecting immune or muscle cells viability, retaining the potentiality to counteract Th1 driven overreactivity established by the self-enhancing inflammatory loop between immune and skeletal muscle cells.
This review summarizes those features of VDR agonists as candidates in future treatment of IM.
American Psychological Association (APA)
Crescioli, Clara. 2014. Vitamin D Receptor Agonists : Suitable Candidates as Novel Therapeutic Options in Autoimmune Inflammatory Myopathy. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-510681
Modern Language Association (MLA)
Crescioli, Clara. Vitamin D Receptor Agonists : Suitable Candidates as Novel Therapeutic Options in Autoimmune Inflammatory Myopathy. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-510681
American Medical Association (AMA)
Crescioli, Clara. Vitamin D Receptor Agonists : Suitable Candidates as Novel Therapeutic Options in Autoimmune Inflammatory Myopathy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-510681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510681