Response to Interferon-Beta Treatment in Afro-Caribbeans with Multiple Sclerosis
Joint Authors
Chausson, N.
Deschamps, R.
Jeannin, S.
Cabre, P.
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-23
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Multiple sclerosis (MS) patients of African ancestry have a more aggressive disease course than white patients and could be resistant to interferon-beta (INFB).
Methods.
We studied the impact of INFB in treatment-naive Afro-Caribbean (AC) with clinically definite MS using our European Database for Multiple Sclerosis (EDMUS) (2003–2010).
Main outcome measures were annual relapse rate after 2 years of treatment, proportion of exacerbation-free subjects 48 weeks after initiating INFB, and time to first relapse.
Results.
76 AC-MS (59F/17M) were identified.
Annual relapse rate of 1.29 decreased to 0.83 (−35.6%) after 2 years of treatment.
The proportion of relapse-free patients at 48 weeks was 46.2%.
Median time to first relapse was 52 weeks.
Conclusion.
INFB is not strong enough to control AC-MS patients in many cases which is problematic in a population of worse MS prognosis.
American Psychological Association (APA)
Jeannin, S.& Deschamps, R.& Chausson, N.& Cabre, P.. 2011. Response to Interferon-Beta Treatment in Afro-Caribbeans with Multiple Sclerosis. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-510697
Modern Language Association (MLA)
Jeannin, S.…[et al.]. Response to Interferon-Beta Treatment in Afro-Caribbeans with Multiple Sclerosis. Multiple Sclerosis International No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-510697
American Medical Association (AMA)
Jeannin, S.& Deschamps, R.& Chausson, N.& Cabre, P.. Response to Interferon-Beta Treatment in Afro-Caribbeans with Multiple Sclerosis. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-510697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510697