Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung
Joint Authors
Kiviat, Nancy B.
Rasey, Janet
Salskov, Alexander
Feng, Qinghua
Jordan, C. Diana
Wiens, Linda
Hawes, Stephen E.
Stern, Joshua E.
Vesselle, Hubert
Lu, Hiep
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It remains unknown whether tobacco smoke induces DNA hypermethylation as an early event in carcinogenesis or as a late event, specific to overt cancer tissue.
Using MethyLight assays, we analyzed 316 lung tissue samples from 151 cancer-free subjects (121 ever-smokers and 30 never-smokers) for hypermethylation of 19 genes previously observed to be hypermethylated in nonsmall cell lung cancers.
Only APC (39%), CCND2 (21%), CDH1 (7%), and RARB (4%) were hypermethylated in >2% of these cancer-free subjects.
CCND2 was hypermethylated more frequently in ever-smokers (26%) than in never-smokers (3%).
CCND2 hypermethylation was also associated with increased age and upper lobe sample location.
APC was frequently hypermethylated in both ever-smokers (41%) and never-smokers (30%).
BVES, CDH13, CDKN2A (p16), CDKN2B, DAPK1, IGFBP3, IGSF4, KCNH5, KCNH8, MGMT, OPCML, PCSK6, RASSF1, RUNX, and TMS1 were rarely hypermethylated (<2%) in all subjects.
Hypermethylation of CCND2 may reflect a smoking-induced precancerous change in the lung.
American Psychological Association (APA)
Salskov, Alexander& Hawes, Stephen E.& Stern, Joshua E.& Feng, Qinghua& Jordan, C. Diana& Wiens, Linda…[et al.]. 2011. Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung. Journal of Oncology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-510701
Modern Language Association (MLA)
Salskov, Alexander…[et al.]. Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung. Journal of Oncology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-510701
American Medical Association (AMA)
Salskov, Alexander& Hawes, Stephen E.& Stern, Joshua E.& Feng, Qinghua& Jordan, C. Diana& Wiens, Linda…[et al.]. Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-510701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510701
