![](/images/graphics-bg.png)
Treatment of Cardiovascular Disease by Traditional Chinese Medicine against Pregnane X Receptor
Joint Authors
Chen, Kuen-Bao
Chen, Calvin Yu-Chian
Chen, Calvin Yu-Chian
Chen, Kuan-Chung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-22
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Recently, cardiovascular disease, also known as loop circulatory system diseases or disorders, is one of the serious diseases including heart disease, stroke, atherosclerosis, myocardial infarction, hypertension, hypotension, and thrombosis.
Human pregnane X receptor, PXR, plays a crucial role in exogenous and endobiotic metabolism for rabbit, rat, mouse, and human.
The PXR activation can protect the blood vessels from damage of hazardous substances.
In this study we aim to investigate the potent lead compounds as PXR receptor agonist against cardiovascular disease.
To improve drug development of TCM compounds, we aim to investigate the potent lead compounds as PXR agonists from the TCM compounds in TCM Database@Taiwan.
The top three TCM compounds, bis(4-hydroxybenzyl) ether mono-β-D-glucopyranoside (BEMG), ixerisoside, and tangshenoside II, have displayed higher potent binding affinities than the positive control, PNU-142721, in the docking simulation.
After MD simulations, which can optimize the result of docking simulation and validate the stability of H-bonds between each ligand and PXR protein under dynamic conditions, top TCM compounds, BEMG and tangshenoside II, maintain most of interactions with PXR protein, which keep the ligand binding stable in the binding domain.
Hence, we propose BEMG and tangshenoside II as potential lead compounds for further study in drug development process with the PXR protein.
American Psychological Association (APA)
Chen, Kuen-Bao& Chen, Calvin Yu-Chian& Chen, Kuan-Chung& Chen, Calvin Yu-Chian. 2014. Treatment of Cardiovascular Disease by Traditional Chinese Medicine against Pregnane X Receptor. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-510707
Modern Language Association (MLA)
Chen, Kuen-Bao…[et al.]. Treatment of Cardiovascular Disease by Traditional Chinese Medicine against Pregnane X Receptor. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-510707
American Medical Association (AMA)
Chen, Kuen-Bao& Chen, Calvin Yu-Chian& Chen, Kuan-Chung& Chen, Calvin Yu-Chian. Treatment of Cardiovascular Disease by Traditional Chinese Medicine against Pregnane X Receptor. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-510707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510707