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Aging and Osteoarthritis : An Inevitable Encounter?
Joint Authors
Hügle, Thomas
Geurts, Jeroen
Valderrabano, Victor
Müller-Gerbl, Magdalena
Nüesch, Corina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Osteoarthritis (OA) is a major health burden of our time.
Age is the most prominent risk factor for the development and progression of OA.
The mechanistic influence of aging on OA has different facets.
On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function.
Collagen cross-linking within the bone results in impaired plasticity and increased stiffness.
Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA.
In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint.
Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA.
It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms.
Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass.
A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system.
New treatment strategies, for example with mesenchymal stem cells (MSC) are investigated, despite clear evidence for their efficacy is lacking.
American Psychological Association (APA)
Hügle, Thomas& Geurts, Jeroen& Nüesch, Corina& Müller-Gerbl, Magdalena& Valderrabano, Victor. 2012. Aging and Osteoarthritis : An Inevitable Encounter?. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510708
Modern Language Association (MLA)
Hügle, Thomas…[et al.]. Aging and Osteoarthritis : An Inevitable Encounter?. Journal of Aging Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-510708
American Medical Association (AMA)
Hügle, Thomas& Geurts, Jeroen& Nüesch, Corina& Müller-Gerbl, Magdalena& Valderrabano, Victor. Aging and Osteoarthritis : An Inevitable Encounter?. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510708