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MicroRNAs as Novel Biomarkers for Breast Cancer
Joint Authors
Sweeney, K. J.
Lowery, Aoife
Heneghan, H. M.
Kerin, Michael J.
Miller, N.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Breast cancer is a complex phenotypically diverse genetic disease, involving a variety of changes in gene expression and structure.
Recent advances in molecular profiling technology have made great progress in unravelling the molecular taxonomy of breast cancer, which has shed new light on the aetiology of the disease and also heralded great potential for the development of novel biomarkers and therapeutic targets.
Mi(cro)RNAs are a contemporary class of small noncoding endogenous RNA molecules, generating great excitement in the clinical and scientific communities.
The recent discovery that miRNA expression is frequently dysregulated in cancer has uncovered an entirely new repertoire of molecular factors upstream of gene expression, which warrants extensive investigation to further elucidate their precise role in malignancy.
We present a comprehensive and timely review of the role of miRNAs in cancer: addressing miRNA function, their putative role as oncogenes or tumor suppressors, with a particular emphasis on breast cancer throughout.
We discuss the recent discovery of quantifiable circulating cancer-associated miRNAs, which heralds immense potential for their use as novel minimally invasive biomarkers for breast and other cancers.
Finally, we comment on the potential role of miRNAs in breast cancer management, particularly in improving current prognostic tools and achieving the goal of individualized cancer treatment.
American Psychological Association (APA)
Heneghan, H. M.& Miller, N.& Lowery, Aoife& Sweeney, K. J.& Kerin, Michael J.. 2009. MicroRNAs as Novel Biomarkers for Breast Cancer. Journal of Oncology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-510710
Modern Language Association (MLA)
Heneghan, H. M.…[et al.]. MicroRNAs as Novel Biomarkers for Breast Cancer. Journal of Oncology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-510710
American Medical Association (AMA)
Heneghan, H. M.& Miller, N.& Lowery, Aoife& Sweeney, K. J.& Kerin, Michael J.. MicroRNAs as Novel Biomarkers for Breast Cancer. Journal of Oncology. 2009. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-510710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510710