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Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages
Joint Authors
Prada-Arismendy, Jeanette
Rincón, Verónica
Castellanos, Jaime E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Infection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock.
The reason for such variability remains unknown.
This work evaluated the in vitro permissiveness of mouse, rat, hamster and guinea pig macrophages to infection by dengue virus 2 (DENV2).
The results established that macrophages derived from the BALB/c mouse strain showed higher permissiveness to DENV2 infection than macrophages from other rodent species, although all rodent species studied had the C820T mutation in the oligoadenylate synthetase 1b gene, indicating no relationship to the different in vitro susceptibilities of mouse cells at this locus.
Other molecular mechanisms related to flavivirus susceptibility remain to be explored.
American Psychological Association (APA)
Prada-Arismendy, Jeanette& Rincón, Verónica& Castellanos, Jaime E.. 2012. Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510722
Modern Language Association (MLA)
Prada-Arismendy, Jeanette…[et al.]. Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages. Journal of Tropical Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-510722
American Medical Association (AMA)
Prada-Arismendy, Jeanette& Rincón, Verónica& Castellanos, Jaime E.. Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510722