Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer
Joint Authors
Sampl, Sandra
Hauck, Marlene
Steinhoff, Heinrich
Grunt, Thomas
Holzmann, Klaus
Kleiter, Miriam
Heinzle, Christine
Marian, Brigitte
Reichmann, Nicole
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Alternative splicing of the IgIII loop of fibroblast growth factor receptors (FGFRs) 1–3 produces b- and c-variants of the receptors with distinctly different biological impact based on their distinct ligand-binding spectrum.
Tissue-specific expression of these splice variants regulates interactions in embryonic development, tissue maintenance and repair, and cancer.
Alterations in FGFR2 splicing are involved in epithelial mesenchymal transition that produces invasive, metastatic features during tumor progression.
Recent research has elucidated regulatory factors that determine the splice choice both on the level of exogenous signaling events and on the RNA-protein interaction level.
Moreover, methodology has been developed that will enable the in depth analysis of splicing events during tumorigenesis and provide further insight on the role of FGFR 1–3 IIIb and IIIc in the pathophysiology of various malignancies.
This paper aims to summarize expression patterns in various tumor types and outlines possibilities for further analysis and application.
American Psychological Association (APA)
Holzmann, Klaus& Grunt, Thomas& Heinzle, Christine& Sampl, Sandra& Steinhoff, Heinrich& Reichmann, Nicole…[et al.]. 2011. Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-510749
Modern Language Association (MLA)
Holzmann, Klaus…[et al.]. Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer. Journal of Nucleic Acids No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-510749
American Medical Association (AMA)
Holzmann, Klaus& Grunt, Thomas& Heinzle, Christine& Sampl, Sandra& Steinhoff, Heinrich& Reichmann, Nicole…[et al.]. Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer. Journal of Nucleic Acids. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-510749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510749