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Comparison of Gene and Protein Expressions in Rats Residing in Standard Cages with Those Having Access to an Exercise Wheel
Joint Authors
Hagerman, Ann E.
Alessio, Helaine M.
Ansinelli, Hayden
Threadgill, Caitlyn
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lifelong physical inactivity is associated with morbidity in adulthood, possibly influenced by changes in gene and protein expressions occurring earlier in life.
mRNA (Affymetrix gene array) and proteomic (2D-DIGE MALDI-TOF/MS) analyses were determined in cardiac tissue of young (3 months) and old (16 months) Sprague-Dawley rats housed with no access to physical activity (SED) versus an exercise wheel (EX).
Unfavorable phenotypes for body weight, dyslipidemia, and tumorogenesis appeared more often in adult SED versus EX.
No differentially expressed genes (DEGs) occurred between groups at 3 or 16 months.
Within groups, SED and EX shared 215 age-associated DEGs.
In SED, ten unique DEGs occurred with age; three had cell adhesion functions (fn1, lgals3, ncam2).
In EX, five unique DEGs occurred with age; two involved hypothalamic, pituitary, and gonadal hormone axis (nrob2, xpnpep2).
Protein expression involved in binding, sugar metabolic processes, and vascular regulation declined with age in SED (KNT1, ALBU, GPX1, PYGB, LDHB, G3P, PYGM, PGM1, ENOB).
Protein expression increased with age in EX for ATP metabolic processes (MYH6, MYH7, ATP5J, ATPA) and vascular function (KNT1, ALBU, GPX1).
Differences in select gene and protein expressions within sedentary and active animals occurred with age and contributed to distinct health-related phenotypes in adulthood.
American Psychological Association (APA)
Alessio, Helaine M.& Ansinelli, Hayden& Threadgill, Caitlyn& Hagerman, Ann E.. 2014. Comparison of Gene and Protein Expressions in Rats Residing in Standard Cages with Those Having Access to an Exercise Wheel. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510750
Modern Language Association (MLA)
Alessio, Helaine M.…[et al.]. Comparison of Gene and Protein Expressions in Rats Residing in Standard Cages with Those Having Access to an Exercise Wheel. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-510750
American Medical Association (AMA)
Alessio, Helaine M.& Ansinelli, Hayden& Threadgill, Caitlyn& Hagerman, Ann E.. Comparison of Gene and Protein Expressions in Rats Residing in Standard Cages with Those Having Access to an Exercise Wheel. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510750