Abnormal Movements of Japanese Infants following Treatment with Midazolam in a Neonatal Intensive Care Unit : Incidence and Risk Factors
Joint Authors
Irikura, Mitsuru
Ishitsuka, Yoichi
Kawase, Akihiko
Kondo, Yuichi
Minami, Eri
Irie, Tetsumi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Background.
This study was conducted to investigate the incidence of, and factors associated with, myoclonus-like abnormal movements of Japanese infants following treatment with midazolam in a neonatal intensive care unit (NICU).
Methods.
We retrospectively investigated abnormal movements and associated risk factors in Japanese infants (less than 1 year old) who received continuous intravenous midazolam treatment in the NICU of the Neonatal Medical Center, Kumamoto City Hospital, Japan, between April 2007 and March 2009.
Results.
The study included 94 infants who received 119 sessions of midazolam treatment in total.
Nine infants (9.6%) developed abnormal movements attributable to midazolam.
These nine patients had a significantly lower gestational age at birth, a significantly lower number of weeks after conception at the start of midazolam treatment, and significantly lower body weight compared with patients free of abnormal movements.
Logistic regression analysis revealed neonatal asphyxia as a factor associated with an elevated risk of abnormal movements (P=0.03).
Conclusion.
The incidence of abnormal movements after midazolam treatment was about 9.6% among the Japanese NICU infants.
This result suggests that neonatal asphyxia may be involved in the onset of abnormal movements in infants treated with midazolam.
American Psychological Association (APA)
Irikura, Mitsuru& Minami, Eri& Ishitsuka, Yoichi& Kawase, Akihiko& Kondo, Yuichi& Irie, Tetsumi. 2012. Abnormal Movements of Japanese Infants following Treatment with Midazolam in a Neonatal Intensive Care Unit : Incidence and Risk Factors. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510761
Modern Language Association (MLA)
Irikura, Mitsuru…[et al.]. Abnormal Movements of Japanese Infants following Treatment with Midazolam in a Neonatal Intensive Care Unit : Incidence and Risk Factors. ISRN Pharmacology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-510761
American Medical Association (AMA)
Irikura, Mitsuru& Minami, Eri& Ishitsuka, Yoichi& Kawase, Akihiko& Kondo, Yuichi& Irie, Tetsumi. Abnormal Movements of Japanese Infants following Treatment with Midazolam in a Neonatal Intensive Care Unit : Incidence and Risk Factors. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510761