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Consistency of Mycobacterium tuberculosis-Specific Interferon-Gamma Responses in HIV-1-Infected Women during Pregnancy and Postpartum
Joint Authors
Jonnalagadda, Sasi R.
Tapia, Kenneth
Farquhar, Carey
Cranmer, Lisa M.
John-Stewart, Grace C.
Wamalwa, Dalton
Lohman-Payne, Barbara
Brown, Elizabeth
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
We determined the consistency of positive interferon-gamma (IFN-γ) release assays (IGRAs) to detect latent TB infection (LTBI) over one-year postpartum in HIV-1-infected women.
Methods.
Women with positive IGRAs during pregnancy had four 3-monthly postpartum IGRAs.
Postpartum change in magnitude of IFN-γ response was determined using linear mixed models.
Results.
Among 18 women with positive pregnancy IGRA, 15 (83%) had a subsequent positive IGRA; 9 (50%) were always positive, 3 (17%) were always negative, and 6 (33%) fluctuated between positive and negative IGRAs.
Women with pregnancy IGRA IFN-γ >8 spot forming cells (SFCs)/well were more likely to have consistent postpartum IGRA response (odds ratio: 10.0; 95% confidence interval (CI): 0.9–117.0).
Change in IFN-γ response over postpartum was 10.2 SFCs/well (95% CI: −1.5–21.8 SFCs/well).
Conclusion.
Pregnancy positive IGRAs were often maintained postpartum with increased consistency in women with higher baseline responses.
There were modest increases in magnitude of IGRA responses postpartum.
American Psychological Association (APA)
Jonnalagadda, Sasi R.& Brown, Elizabeth& Lohman-Payne, Barbara& Wamalwa, Dalton& Farquhar, Carey& Tapia, Kenneth…[et al.]. 2012. Consistency of Mycobacterium tuberculosis-Specific Interferon-Gamma Responses in HIV-1-Infected Women during Pregnancy and Postpartum. Infectious Diseases in Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510765
Modern Language Association (MLA)
Jonnalagadda, Sasi R.…[et al.]. Consistency of Mycobacterium tuberculosis-Specific Interferon-Gamma Responses in HIV-1-Infected Women during Pregnancy and Postpartum. Infectious Diseases in Obstetrics and Gynecology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-510765
American Medical Association (AMA)
Jonnalagadda, Sasi R.& Brown, Elizabeth& Lohman-Payne, Barbara& Wamalwa, Dalton& Farquhar, Carey& Tapia, Kenneth…[et al.]. Consistency of Mycobacterium tuberculosis-Specific Interferon-Gamma Responses in HIV-1-Infected Women during Pregnancy and Postpartum. Infectious Diseases in Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510765