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HAX1 Augments Cell Proliferation, Migration, Adhesion, and Invasion Induced by Urokinase-Type Plasminogen Activator Receptor
Joint Authors
Pourgholami, Mohammad Hossein
Morris, David Lawson
Mekkawy, Ahmed H.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The urokinase-type plasminogen activator receptor (uPAR) is a cell surface receptor which has a multifunctional task in the process of tumorigenesis including cell proliferation, adhesion, migration, and invasion.
Many of the biological functions of uPAR necessitate interactions with other proteins.
We have shown previously that uPAR interacts with HAX1 protein (HS-1-associated protein X-1).
In the current study, to gain insight into the possible role of HAX1 overexpression in regulation of uPAR signal transduction pathway, several function assays were used.
We found that, upon stimulation of uPAR, HAX1 colocalizes with uPAR suggesting a physiological role for HAX1 in the regulation of uPAR signal transduction.
HAX1 overexpression augments cell proliferation and migration in uPAR-stimulated cells.
Moreover, HAX1 over-expression augmented uPAR-induced cell adhesion to vitronectin as well as cellular invasion.
Our results suggest that HAX1 over-expression may underlay a novel mechanism to regulate uPAR-induced functions in cancer cells.
American Psychological Association (APA)
Mekkawy, Ahmed H.& Morris, David Lawson& Pourgholami, Mohammad Hossein. 2012. HAX1 Augments Cell Proliferation, Migration, Adhesion, and Invasion Induced by Urokinase-Type Plasminogen Activator Receptor. Journal of Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-510775
Modern Language Association (MLA)
Mekkawy, Ahmed H.…[et al.]. HAX1 Augments Cell Proliferation, Migration, Adhesion, and Invasion Induced by Urokinase-Type Plasminogen Activator Receptor. Journal of Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-510775
American Medical Association (AMA)
Mekkawy, Ahmed H.& Morris, David Lawson& Pourgholami, Mohammad Hossein. HAX1 Augments Cell Proliferation, Migration, Adhesion, and Invasion Induced by Urokinase-Type Plasminogen Activator Receptor. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-510775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510775