Association of IRGM Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran

Joint Authors

Taheri, Mohsen
Atabaki, Mahdi
Bahari, Gholamreza
Naderi, Mohammad
Eskandari-Nasab, Ebrahim
Hashemi, Mohammad

Source

The Scientific World Journal

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-09-23

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science

Abstract EN

Tuberculosis (TB) is a major cause of morbidity and mortality worldwide.

IRGM1 is an important protein in the innate immune response against intracellular pathogens by regulating autophagy.

Polymorphisms in the IRGM genes are known to influence expression levels and may be associated with outcome of infections.

This case-control study was done on 150 patients with PTB and 150 healthy subjects to determine whether the IRGM polymorphisms at positions −1208 A/G (rs4958842), −1161 C/T (rs4958843), and −947 C/T (rs4958846) were associated with PTB.

The polymorphisms were determined using tetra-amplification refractory mutation system-PCR (T-ARMS-PCR).

The results showed that the IRGM −1161 C/T and −947 C/T polymorphisms were associated with decreased susceptibility to PTB (OR = 0.06, 95% CI = 0.03–0.13, P < 0.001 and OR = 0.27; 95% CI = 0.013–0.55, P < 0.001, resp.).

No significant difference was found among the groups regarding −1208 A/G polymorphism.

In conclusion we found that the IRGM −1161 C/T and −947 C/T polymorphisms but not −1208 A/G polymorphism provide relative protection against PTB in a sample of Iranian population.

American Psychological Association (APA)

Bahari, Gholamreza& Hashemi, Mohammad& Taheri, Mohsen& Naderi, Mohammad& Eskandari-Nasab, Ebrahim& Atabaki, Mahdi. 2012. Association of IRGM Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510782

Modern Language Association (MLA)

Bahari, Gholamreza…[et al.]. Association of IRGM Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-510782

American Medical Association (AMA)

Bahari, Gholamreza& Hashemi, Mohammad& Taheri, Mohsen& Naderi, Mohammad& Eskandari-Nasab, Ebrahim& Atabaki, Mahdi. Association of IRGM Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510782

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-510782