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Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
Joint Authors
Yuan, Dong-ping
Wei, Wei
Zhou, Ling-ling
Si, Jun-feng
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) develops in relation to many environmental factors.
In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE.
In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice.
Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks.
IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection.
The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks.
Renal lesions were also observed.
The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies.
Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production.
Besides, melatonin could lessen the renal lesions caused by pristane.
These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances.
American Psychological Association (APA)
Zhou, Ling-ling& Wei, Wei& Si, Jun-feng& Yuan, Dong-ping. 2010. Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-510812
Modern Language Association (MLA)
Zhou, Ling-ling…[et al.]. Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-510812
American Medical Association (AMA)
Zhou, Ling-ling& Wei, Wei& Si, Jun-feng& Yuan, Dong-ping. Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-510812
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510812