Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva
Joint Authors
Ueda, Yutaka
Kimura, Toshihiro
Kimura, Tadashi
Fujita, Masami
Enomoto, Takayuki
Yoshino, Kiyoshi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Squamous cell carcinoma (SCC) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women.
The future numbers of patients with vulvar SCC is expected to rise, mainly because of the proportional increase in the average age of the general population.
Two different pathways for vulvar SCC have been put forth.
The first pathway is triggered by infection with a high-risk-type Human Papillomavirus (HPV).
Integration of the HPV DNA into the host genome leads to the development of a typical vulvar intraepithelial neoplasia (VIN), accompanied with overexpression of p14ARF and p16INK4A.
This lesion subsequently forms a warty- or basaloid-type SCC.
The HPV vaccine is a promising new tool for prevention of this HPV related SCC of the vulva.
The second pathway is HPV-independent.
Keratinizing SCC develops within a background of lichen sclerosus (LS) through a differentiated VIN.
It has a different set of genetic alterations than those in the first pathway, including p53 mutations, allelic imbalances (AI), and microsatellite instability (MSI).
Further clinical and basic research is still required to understand and prevent vulvar SCC.
Capsule.
Two pathway for pathogenesis of squamous cell carcinoma of the value are reviewed.
American Psychological Association (APA)
Ueda, Yutaka& Enomoto, Takayuki& Kimura, Toshihiro& Yoshino, Kiyoshi& Fujita, Masami& Kimura, Tadashi. 2010. Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva. Journal of Skin Cancer،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510819
Modern Language Association (MLA)
Ueda, Yutaka…[et al.]. Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva. Journal of Skin Cancer No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-510819
American Medical Association (AMA)
Ueda, Yutaka& Enomoto, Takayuki& Kimura, Toshihiro& Yoshino, Kiyoshi& Fujita, Masami& Kimura, Tadashi. Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva. Journal of Skin Cancer. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510819