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C-Glycosidic Genistein Conjugates and Their Antiproliferative Activity
Joint Authors
Papaj, Katarzyna
Szeja, Wiesław
Grynkiewicz, Grzegorz
Rusin, Aleksandra
Chrubasik, Maciej
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This paper presents our attempt to investigate scopes and the limitations of olefin cross-metathesis (CM) reaction in the synthesis of complex C-glycosides of genistein and evaluation of their antiproliferative activities.
Novel genistein glycoconjugates were synthesized with the utility of CM reaction initiated by first and second generation of Grubbs catalysts.
The relative reactivity of utilized olefins, based on categories proposed by Grubbs, was estimated.
In vitro experiments in cancer cell lines showed that the selected derivatives (3a and 3f) exhibited higher antiproliferative potential than the parent compound, genistein, and were able to block the cell cycle in the G2/M phase.
The observed mechanism of action of C-glycosidic derivatives was similar to the activity of their O-glycosidic counterparts.
These compounds were stable in culture medium.
The obtained results show that our approach to genistein modification with application of cross-metathesis reaction allowed to obtain stable glycoconjugates with improved anticancer potential, compared to the parent isoflavone.
American Psychological Association (APA)
Rusin, Aleksandra& Chrubasik, Maciej& Papaj, Katarzyna& Grynkiewicz, Grzegorz& Szeja, Wiesław. 2013. C-Glycosidic Genistein Conjugates and Their Antiproliferative Activity. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-510845
Modern Language Association (MLA)
Rusin, Aleksandra…[et al.]. C-Glycosidic Genistein Conjugates and Their Antiproliferative Activity. Journal of Chemistry No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-510845
American Medical Association (AMA)
Rusin, Aleksandra& Chrubasik, Maciej& Papaj, Katarzyna& Grynkiewicz, Grzegorz& Szeja, Wiesław. C-Glycosidic Genistein Conjugates and Their Antiproliferative Activity. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-510845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510845