Cerebroprotective Effect of Moringa oleifera against Focal Ischemic Stroke Induced by Middle Cerebral Artery Occlusion
Joint Authors
Wattanathorn, Jintanaporn
Tong-Un, Terdthai
Wannanon, Panakaporn
Muchimapura, Supaporn
Jittiwat, Jinatta
Kirisattayakul, Woranan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The protection against ischemic stroke is still required due to the limitation of therapeutic efficacy.
Based on the role of oxidative stress in stroke pathophysiology, we determined whether Moringa oleifera, a plant possessing potent antioxidant activity, protected against brain damage and oxidative stress in animal model of focal stroke.
M.
oleifera leaves extract at doses of 100, 200 and 400 mg·kg−1 was orally given to male Wistar rats (300–350 g) once daily at a period of 2 weeks before the occlusion of right middle cerebral artery (Rt.MCAO) and 3 weeks after Rt.MCAO.
The determinations of neurological score and temperature sensation were performed every 7 days throughout the study period, while the determinations of brain infarction volume, MDA level, and the activities of SOD, CAT, and GSH-Px were performed 24 hr after Rt.MCAO.
The results showed that all doses of extract decreased infarction volume in both cortex and subcortex.
The protective effect of medium and low doses of extract in all areas occurred mainly via the decreased oxidative stress.
The protective effect of the high dose extract in striatum and hippocampus occurred via the same mechanism, whereas other mechanisms might play a crucial role in cortex.
The detailed mechanism required further exploration.
American Psychological Association (APA)
Kirisattayakul, Woranan& Wattanathorn, Jintanaporn& Tong-Un, Terdthai& Muchimapura, Supaporn& Wannanon, Panakaporn& Jittiwat, Jinatta. 2013. Cerebroprotective Effect of Moringa oleifera against Focal Ischemic Stroke Induced by Middle Cerebral Artery Occlusion. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510848
Modern Language Association (MLA)
Kirisattayakul, Woranan…[et al.]. Cerebroprotective Effect of Moringa oleifera against Focal Ischemic Stroke Induced by Middle Cerebral Artery Occlusion. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-510848
American Medical Association (AMA)
Kirisattayakul, Woranan& Wattanathorn, Jintanaporn& Tong-Un, Terdthai& Muchimapura, Supaporn& Wannanon, Panakaporn& Jittiwat, Jinatta. Cerebroprotective Effect of Moringa oleifera against Focal Ischemic Stroke Induced by Middle Cerebral Artery Occlusion. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510848