Mitochondria, Cognitive Impairment, and Alzheimer's Disease
Joint Authors
Carlesi, C.
Calsolaro, V.
Choub, A.
Mancuso, Michelangelo
Orsucci, Daniele
Siciliano, Gabriele
Piazza, S.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To date, the beta amyloid (Aβ) cascade hypothesis remains the main pathogenetic model of Alzheimer's disease (AD), but its role in the majority of sporadic AD cases is unclear.
The “mitochondrial cascade hypothesis” could explain many of the biochemical, genetic, and pathological features of sporadic AD.
Somatic mutations in mitochondrial DNA (mtDNA) could cause energy failure, increased oxidative stress, and accumulation of Aβ, which in a vicious cycle reinforce the mtDNA damage and the oxidative stress.
Despite the evidence of mitochondrial dysfunction in AD, no causative mutations in the mtDNA have been detected so far.
Indeed, results of studies on the role of mtDNA haplogroups in AD are controversial.
In this review we discuss the role of the mitochondria, and especially of the mtDNA, in the cascade of events leading to neurodegeneration, dementia, and AD.
American Psychological Association (APA)
Mancuso, Michelangelo& Calsolaro, V.& Orsucci, Daniele& Carlesi, C.& Choub, A.& Piazza, S.…[et al.]. 2009. Mitochondria, Cognitive Impairment, and Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-510860
Modern Language Association (MLA)
Mancuso, Michelangelo…[et al.]. Mitochondria, Cognitive Impairment, and Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-510860
American Medical Association (AMA)
Mancuso, Michelangelo& Calsolaro, V.& Orsucci, Daniele& Carlesi, C.& Choub, A.& Piazza, S.…[et al.]. Mitochondria, Cognitive Impairment, and Alzheimer's Disease. International Journal of Alzheimer's Disease. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-510860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510860